PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Produits associés (4114)
Produits associés (4114)
-
PROTAC Linkers Isoform Comparison
-
7-Bromoheptanoyl chloride
0 ImagesCat. No.: HY-161613CAS No.: 50733-91-0
-
1-(2-Bromoethyl)piperazine
0 ImagesCat. No.: HY-W840791CAS No.: 494798-96-8
-
N1,N4-dimethylcyclohexane-1,4-diamine
0 ImagesCat. No.: HY-W376544CAS No.: 2678-67-3
-
N-(m-PEG4)-N'-(hydroxy-PEG2)-Cy5
0 ImagesCat. No.: HY-141073CAS No.: 2107273-12-9
-
tert-Butyl ((3-aminocyclobutyl)methyl)(methyl)carbamate
0 ImagesCat. No.: HY-W539429CAS No.: 1489063-08-2
-
(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline
0 ImagesCat. No.: HY-168303(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is a connector for PROTAC, which can be used to synthesize (R)-NX-2127 (HY-153220A) and is utilized in research within the field of malignant tumors.
-
4-(2-Aminoethyl)cyclohexan-1-amine
0 ImagesCat. No.: HY-W353339CAS No.: 202256-86-8
-
Boc-Octahydrocyclopenta[c]pyrrole-amino
![Boc-Octahydrocyclopenta[c]pyrrole-amino](https://file.medchemexpress.com/product_pic/hy-w043851.gif "Click to View Boc-Octahydrocyclopenta[c]pyrrole-amino Product Detail")
0 ImagesCat. No.: HY-W043851CAS No.: 1031335-28-0
-
Di-tert-butyl adipate
0 ImagesCat. No.: HY-W102193CAS No.: 20270-53-5
-
tert-Butyl (2-(azetidin-3-yl)ethyl)carbamate
0 ImagesCat. No.: HY-40346CAS No.: 162696-31-3
-
11-Hydroxyundecanoic acid
0 ImagesCat. No.: HY-W142804CAS No.: 3669-80-5
-
Boc-PEG3-I
0 ImagesCat. No.: HY-W612537CAS No.: 1291090-50-0
-
3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid
![3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid](https://file.medchemexpress.com/product_pic/hy-w120542.gif "Click to View 3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid Product Detail")
0 ImagesCat. No.: HY-W120542CAS No.: 2024542-05-8
-
tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate
![tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w1115289.gif "Click to View tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate Product Detail")
0 ImagesCat. No.: HY-W1115289CAS No.: 2434847-28-4
-
15-Bromopentadecanoic acid
0 ImagesCat. No.: HY-W007241CAS No.: 56523-59-2
